REACH
REACH – Registration, Evaluation, Authorization and Restriction of Chemical Substances.
REACH is European Community Regulation on chemicals and their safe use (EC 1907/2006). The law entered into force on 1 June 2007. The regulation concerns manufacturers/importers, producers, suppliers, distributors and downstream users.
BioTest is capable to provide or organize comprehensive testing program including physico chemical properties, ecotoxicity studies and studies for reproduction in cooperation with partner GLP-certified organizations. Simply said, we are flexible enough to organize comprehensive package service.
| Acute toxicity | |
| Acute toxicity (oral, dermal, parenteral,), rodents | OECD 402 420, 423,425, OPTTS 870-110, 885.3200, 885.3150, 885.3300, ISO 10993-11 |
| Irritation (skin, eye, respiratory), rabbit | ISO 10993-10, OECD 404, 405, OPTTS 870-2500 |
| Sensitization (skin, respiratory), guinea pig, Local lymph node assay | ISO 10993-10, OECD 406, OPTTS 870-2600, OECD 429 |
| Repeated dose toxicity | |
| 14/28-day toxicity study, rodents, non-rodents | OECD 408, 409, 410, OPTTS 870-3050, |
| 90-day toxicity study, rodents, non-rodents | OECD 408, 409, 411 1981, OPTTS 870-3100, OPTTS 870-3150, OPTTS 870-3250 |
| 6/9/12-month toxicity study, rodents, non-rodents | OECD 452, OPTTS 870-4100 |
| Toxicokinetics , rodents, non-rodents | OECD 417, OPTTS 870-7485, 870-8223 |
| Mutagenicity | |
| Salmonella typhimurium reverse mutation test | OECD 471, OPTTS 870-5100 |
| Salmonella typhimurium + E. coli reverse mutation test | OECD 471, OPTTS 870-5265 |
| Cytotoxicity in vitro | ISO 10993-5 |
| Mammalian erythrocyte micronucleus test, in vivo, rodents | OECD 474, OPTTS 870-5395 |
| Erythrocyte micronucleus test, in vitro, | OECD draft 479 |
| In vitro mammalian chromosome aberration test, human lymphocytes | OECD 473 |
| Carcinogenicity | |
| Carcinogenicity | OECD 451 |
| Combined chronic toxicity/carcinogenicity | OECD 453 |
| Ecotoxicity | |
| Acute fish toxicity test, | EU C.1, OECD 203 |
| Daphnia sp. Acute immobilization test, static, semi-static | EU C.2, OECD 202 |
| Growth inhibition test, algae | EU C.11, OECD 201 2002 |
| Acute toxicity test, earthworms | OECD 207 1984 |
| Respiration inhibition, activated sludge | OECD 209 |
| Daphnia reproduction, 21 day, semi-static | OECD 211 |
| Fish early life stage toxicity, Zebra fish, semi-static | OECD 210 |
| Fish embryo and sac-fry toxicity, Zebra fish | OECD 212 |
| Fish juvenile growth, Zebra fish | OECD 215 |
| Soil microorganismus: N2 transformation, 28 days | OECD 216 |
| Earthworm reproduction test, 8 weeks | OECD 222 |
| Terrestrial plants growth | OECD 208 |
| Sediment-water chironomid toxicity test using spiked sediment | OECD 218 |
| Sediment-water chironomid toxicity test using spiked water | OECD 219 |
| Bird reproduction toxicity, Japanese quail | OECD 206 |
| Ready biodegradability | |
| Ready Biodegradability: Closed Bottle Test | OECD 301D |
| Ready Biodegradability: Modified OECD Screening Test | OECD 301E |
| Ready Biodegradability: Manometric respirometry test | OECD 301F |
| Soil simulation | OECD 307 |
| Inherent biodegradability: Zahn Wellens test | OECD 302B |
| Environmental fate studies | |
| Hydrolysis, preliminary | OECD 111 |
| Hydrolysis, preliminary and main test | OECD 111 |
| Chemical physical properties | |
| Melting point, boiling point | OECD 102, 103 |
| Relative Density, Vapor Pressure | OECD 109, 104 |
| Surface Tension | OECD 109, 115 |
| Water solubility | OECD 109, 105 |
| Partition coefficient | OECD 117, 105 |
| Adsorption/Desorption | OECD 121, 105 |
| Dissociation constants in water | OECD 121, |
| Flash point, liquides | OECD EU A.9 |
| Flammability, solids | OECD EU A.10 |
| Self-ignition temperature, solids | OECD EU A.16 |
| Oxidizing properties, solids | OECD EU A.17 |
| Pyrophoric properties of solids and liquids | OECD EU A.13 |